A Novel Approach to High-Throughput Screening
نویسندگان
چکیده
منابع مشابه
A high-throughput screening approach to discovering
While many models of biological object recognition share a common set of ‘‘broad-stroke’’ properties, the performance of any one model depends strongly on the choice of parameters in a particular instantiation of that model—e.g., the number of units per layer, the size of pooling kernels, exponents in normalization operations, etc. Since the number of such parameters (explicit or implicit) is t...
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The high-throughput search described in this paper takes advantage of multiple levels of parallelism, from coarse to fine-grained. Roughly speaking, fine-grained parallelism is exploited by allocating one core (of which modern graphics hardware have many; and their number is exponentially growing over the years) to one or more virtual neurons, while coarse-scale parallelism is achieved by alloc...
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A high-throughput screening approach was used to identify new inhibitors of the metallo-protease lethal factor from Bacillus anthracis. A library of approximately 14,000 compounds was screened using a fluorescence-based in vitro assay and hits were further characterized enzymatically via measurements of IC50 and Ki values against a small panel of metallo-proteases. This study led to the identif...
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ABSTRACT Background and Objectives: Blood transfusion may induce some adverse effects on receivers. Some methods such as antibody screening and cross matching have been suggested to reduce the risk of transfusion complications. However, these methods require commercial antibody screening kits that may also need special equipment. The aim of this study was t...
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Virtual screening is being routinely used as an integral part of today's hit-identification strategies for, on one hand, prioritizing large corporate screening collections and, on the other hand, to extend the scope of screening to external databases. A brief description of the essential elements required for virtual screening and an application example to the identification of agonist hits for...
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ژورنال
عنوان ژورنال: Structure
سال: 2004
ISSN: 0969-2126
DOI: 10.1016/j.str.2004.06.010